Agent-based model of multicellular tumor spheroid evolution including cell metabolism
نویسندگان
چکیده
منابع مشابه
Agent-Based Simulations of In Vitro Multicellular Tumor Spheroid Growth
Multicellular tumor spheroids (MTS) are an in vitro model system of avascular tumors. They are used to study how local microenvironments affect cellular growth, viability, and therapeutic response. We are developing in silico, agent-based analogues to provide new options for gaining exploitable insight into both the in vitro and in vivo systems. MTS exhibit characteristic phenotypic attributes:...
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Multicellular tumor spheroids (MTS) from seven murine solid tumors have been compared in terms of their growth rate and the fraction of the cells that are in cycle. Growth rates ranged from a low of 19 micron/day through a maximum of 106 micron/day, demonstrating a far wider range of growth rates than is observed when the same tumors are grown as monolayers. Through the use of an [125I]iodourid...
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ژورنال
عنوان ژورنال: The European Physical Journal E
سال: 2019
ISSN: 1292-8941,1292-895X
DOI: 10.1140/epje/i2019-11878-7